Mouse Models
Innovative solutions, from standard models to advanced transgenic models, the Mouse Biology Program has the experience to propel biomedical research into the future.
The Mouse Biology Program (MBP) provides a comprehensive suite of services and resources for mouse models, ranging from generic strains to fully custom models. Here’s a breakdown of the offerings:
Generic Mouse Models
- Repository Access: The MBP maintains a vast collection of genetically engineered and mutant strains available for direct distribution.
- Cryopreserved Lines: Strains preserved as embryos, sperm, or embryonic stem (ES) cells can be shipped worldwide for researchers to reanimate.
- Phenotypically Defined Models: These include models for specific diseases or biological functions already validated for research purposes.
- Importation Services: MBP can handle the logistics and regulatory requirements to bring models into the U.S. or other locations, ensuring compliance with import/export standards.
Custom Mouse Models
- CRISPR-Cas9 Gene Editing: Design and create models with precise genetic modifications using the latest genome-editing technologies.
- Knockout/Knock-in Models: Generate strains where specific genes are deleted (knockout) or altered/replaced (knock-in).
- Transgenic Models: Creation of mice with integrated genes, reporters, or constructs for studying gene function or expression.
- Conditional Models: Use of systems like Cre-Lox to create tissue-specific or inducible gene alterations.
- Humanized Models: Mice engineered to express human genes, proteins, or cells, ideal for translational research.
Services Bridging Generic and Custom Models
- Phenotyping: Detailed analysis of phenotypic effects in models, including traditional and advanced OMICS services (metabolomics, proteomics, transcriptomics).
- Cryopreservation and Recovery: Storage of genetic material from custom or generic models, with services to resuscitate strains on demand.
- Colony Management: Breeding services for large or small colonies include maintaining genetic integrity and monitoring health.
- Crossbreeding: Assistance with breeding specific genetic backgrounds or combinations from generic or custom strains.
- Rapid Genotyping: Verification of genetic modifications in offspring.
Consultation and Collaboration
- Design Assistance: Expert guidance to help researchers design custom models tailored to specific experimental needs.
- Validation Studies: Comprehensive quality control to ensure genetic modifications achieve the desired outcomes.
- Training: Workshops or one-on-one support on utilizing, phenotype, or managing mouse models effectively.
Specialized Applications
- Disease Models: Mice tailored to mimic human diseases such as cancer, metabolic disorders, and neurological conditions.
- Toxicology Studies: Models for assessing drug efficacy or safety.
- Developmental Biology: Embryonic studies using specialized lines.
- Comparative Research: Leveraging genetic diversity in mice to study evolutionary, genetic, or biomedical phenomena.
International Support
MBP supports researchers globally with logistics for model import/export, regulatory compliance, and distribution to over 30 countries.
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