Driving breakthroughs in inflammatory bowel disease research with specialized mouse models and comprehensive phenotyping services from the Mouse Biology Program.
Our IBD Portfolio provides researchers with essential tools and resources to study the complex mechanisms underlying inflammatory bowel disease (IBD), including Crohn’s disease and ulcerative colitis. We offer specialized mouse models, cutting-edge assays, and expert consultation to support investigations into gut inflammation, immune regulation, microbiome interactions, and therapeutic interventions.
Whether you’re studying disease etiology, testing potential treatments, or analyzing host-microbe dynamics, our IBD resources are designed to enhance the reproducibility and impact of your research with some of the following resources:
Mouse Models for IBD Research
Phenotyping and Functional Analysis
Microbiome and Metabolomic Studies
Preclinical Testing of IBD Therapeutics
Mouse Models for IBD Research
We provide a diverse selection of mouse models for studying IBD, including:
Genetically Engineered Models (GEMMs): For studying specific genetic mutations associated with IBD.
Immune Dysfunction Models: Mice with altered immune pathways to assess immune regulation in intestinal inflammation.
Microbiome-Dependent Models: Gnotobiotic and microbiome-sensitive models to explore host-microbiota interactions.
Phenotyping and Functional Analysis
We offer comprehensive phenotyping services for IBD research, including:
Histopathology of Intestinal Tissue: Detailed analysis of inflammation, epithelial damage, and immune cell infiltration.
Cytokine Profiling: Quantification of pro- and anti-inflammatory cytokines to assess immune responses.
Barrier Function Assays: Evaluation of gut permeability and epithelial integrity.
Microbiome and Metabolomic Studies
Our IBD platform includes resources to assess the role of the microbiome in gut health and disease:
Fecal Microbiota Transfer (FMT): Supports studies on how microbial communities influence disease progression.
Metabolomic Profiling: Analysis of small molecules involved in metabolic and inflammatory pathways.
Preclinical Testing of IBD Therapeutics
Our services support preclinical drug development and testing for IBD therapies:
Drug Efficacy Studies: Evaluation of small molecules, biologics, and dietary interventions in mouse models.
Combination Therapy Testing: Analysis of drug interactions and synergistic effects.
Immune Modulation Studies: Investigation of immune-targeted therapies, such as anti-cytokine agents and immune checkpoint inhibitors.
Why Choose Our IBD Portfolio?
Comprehensive Model Access: From GEMMs to gnotobiotic models, we provide tools for diverse research needs.
Expert Consultation: Guidance on experimental design, model selection, and data interpretation.
Integrated Analysis: Multidimensional phenotyping and microbiome profiling to enhance research outcomes.
Get Started
Advance your IBD research with our specialized models, phenotyping services, and expert support and ask about how the Mouse Biology Program can support your research: