ADMET Portfolio

With the Mouse Biology Program, we support drug development acceleration with comprehensive ADMET testing resources and mouse models.

Our ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicology) Portfolio provides researchers with the tools and expertise to evaluate drug candidates efficiently and accurately. By leveraging specialized mouse models, phenotyping assays, and cutting-edge analytical services, we support preclinical studies to understand pharmacokinetics, pharmacodynamics, and toxicological profiles with some of our advanced services and resources:

Specialized Mouse Models for ADMET Studies
Pharmacokinetics (PK) and Pharmacodynamics (PD) Testing
Toxicology and Safety Assessment
Bioinformatics and Data Analysis

Specialized Mouse Models for ADMET Studies

We provide mouse models tailored for assessing drug safety, metabolism, and response, including:

Humanized Liver Models: For studying human drug metabolism pathways and xenobiotic responses.
Knockout and Transgenic Models: To evaluate specific metabolic or transporter pathways.
Toxicology Screening Models: For assessing systemic and organ-specific toxicological effects.

Pharmacokinetics (PK) and Pharmacodynamics (PD) Testing

Our platform supports in-depth pharmacokinetics and pharmacodynamics studies:

Absorption and Distribution: Tracking drug bioavailability and tissue distribution using labeled compounds and imaging.
Metabolic Profiling: Identification of drug metabolites using OMICS approaches.
Excretion Studies: Analysis of elimination routes and clearance rates.

Toxicology and Safety Assessment

We provide comprehensive toxicology testing services to assess potential adverse effects:

Acute and Chronic Toxicity Studies: To evaluate short- and long-term safety profiles.
Organ-Specific Toxicity: Focused assessments for liver, kidney, and cardiovascular toxicity.
Behavioral and Neurological Screening: To detect potential off-target effects on behavior and cognition.

Why Choose Our ADMET Portfolio?

Comprehensive Solutions: End-to-end support for absorption, distribution, metabolism, excretion, and toxicity studies.
Innovative Models and Tools: Access to humanized and genetically engineered mouse models.
Expert Consultation: Guidance on experimental design, data interpretation, and regulatory reporting.

Get Started

Our comprehensive ADMET testing services and mouse models will enhance your drug development pipeline.

Inquire How MBP can Support Drug Development Efforts

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