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UC Davis Mouse Biology
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Please add a detailed description of your project goals. If you require KO mouse generation, please be sure to indicate the gene, and whether you require a global KO or a conditional KO and the mouse background required. Please also indicate if you require a tag or reporter. If you require a targeted knock-in mouse model please indicate the gene details and any information you may know about the promoter. If you require a transgenic mouse, such as for over expressing a gene, humanizing a mouse or a Cre-expressing mouse, etc., please outline the project goals in as much detail as possible. If you would like your mouse strain archived or re-derived, please let us know the strain name, mouse background and whether you require homozygous or heterozygous strain archiving/rederivation. If you would like your mouse strain resuscitated, please indicate the nature of the archive (sperm or embryos) and where the archive is currently located, such as at your institution, the MBP, a vendor, or a collaborator’s institution. If you require genotyping, please indicate the type of genotyping required and the tissues to be genotyped (mouse tissue, ES cells, DNA etc.) If you require mouse breeding, please outline the details of existing mouse line (if any) and the goals of your project. If you require phenotyping, please provide as much information as possible on your project goals. If you are attempting to replicate results or tests in a particular publication, please reference the journal article. We will contact you to discuss your project in detail and provide a full quote and project proposal before you are obligated to provide any payment information.
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NIH Grant to Create Humanized Mice Susceptible to COVID-19

By Andy Fell on August 3, 2020, in Human & Animal Health

The National Institutes of Health has awarded a grant of $1.2 million to the Mouse Biology Program at the University of California, Davis, to create mice that are susceptible to the COVID-19 virus, and to distribute them to researchers.

The goal is to create mice that can be used to reproduce human COVID-19 disease, said Kent Lloyd, director of the Mouse Biology Program and professor in the Department of Surgery at the UC Davis School of Medicine. Mice and rats are not naturally infected by SARS-CoV-2, the virus that causes COVID-19. The virus enters human cells by attaching to a protein called ACE2. Lloyd’s team plans to create “humanized” laboratory mice by using CRISPR-Cas9 technology to precisely replace the genetic code for the mouse equivalent of ACE2 with the code for human ACE2. They will also do the same with other human proteins thought to play a role in COVID-19 disease, such as TMPRSS2, which is thought to work with ACE2 to get the virus into cells. These lab mice will enable new investigations of how the virus attacks the body, why some people are more susceptible than others, and how COVID-19 might be prevented or treated. As new genes involved in COVID-19 disease are discovered, they could also be engineered into mice, Lloyd said. Researchers might even be able to look at the effect of genetic variations in key genes on the course of disease. Lloyd expects the mice to become available in about six months.

The UC Davis Mouse Biology Program is a member of the NIH-funded Mutant Mouse Resource and Research Centers. The network collects and characterizes gene-modified and genetic knockout lab mice, and makes them available to researchers worldwide. The NIH recently renewed funding for the UC Davis center, now in its 21st year, for another five years.

Media contact(s)

Kent Lloyd, Mouse Biology Program, 530-754-6687,This email address is being protected from spambots. You need JavaScript enabled to view it.

Amy Quinton, News and Media Relations, 530-752-9843, cell 530-601-8077,This email address is being protected from spambots. You need JavaScript enabled to view it.

 

 

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UPDATE: July 30, 2020 MBP Operations Status

UC Davis and the UC Davis Mouse Biology Program remains in Phase 2 recovery and continues to operate with limited on-site staff. Customer service is operating remotely; if you need to contact us, we are available via email or we can schedule a Zoom teleconference (we do not have access to our office phones). We have been given campus authorization to resume some services, specifically those scheduled prior to the shutdown that were halted, as well as some shipping and receiving; we will work closely with institutions and couriers, as there are still flight concerns, to ensure the safety and health of personnel, live animals, and research materials. We are not yet beginning new projects, with the exception of approved UCD research projects*, but can prepare necessary documentation in anticipation of Phase 3. We appreciate your understanding of delays experienced during this time.

 *UC Davis Researchers, the Service and Research Phase2 Request Form will be required for authorization prior to initiating new projects in Phase 2. Please let us know if you would like to begin a new project, or to return a completed form, by emailing This email address is being protected from spambots. You need JavaScript enabled to view it..

 

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UC Davis Mouse Biology Program Responds to Campus Fiscal Challenges

(June 24, 2020, DAVIS, CA) As the University of California Davis prepares for the fiscal impact of funding cuts in the state’s 2020-2021 budget due to the COVID-19 pandemic, the UC Davis Mouse Biology Program (MBP) is taking the unprecedented step by returning $275,000 from its reserve account to the University’s Office of the Provost. In the spirit of campus community, this generous donation comes at a time when the campus is facing unparalleled financial challenges as it deals with the effects of SARS-CoV-2. These funds will allow the Office of the Provost to support campus teaching and research programs with the greatest need.

UCDavis_Mouse_Biology_Program_Responds_to_Campus_Fiscal_Challenges_624.2020.docx

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MBP Now A Special Research Program Under Office Of Research

As the Mouse Biology Program (MBP) begins its third decade of service as a scientific resource for campus researchers, we are pleased to announce that effective March 1st we will join the UC Davis Office of Research. With operational and administrative oversight provided by the Office of Research, this move will place MBP in a better position to support the needs of campus investigators conducting research using mutant mice. This move will also better enable us to provide innovative products, unique services, and specialized infrastructure for research in areas of human and animal health and precision medicine. During this transition, we do not expect any slowdown in delivery or interruption of current or future orders and services to researchers.

Since 1997, the MBP has grown from one small laboratory to a large and vibrant organization playing an essential role in biomedical discovery by facilitating the availability and accessibility of next-generation mouse models and mouse mutagenesis and other strategies. This dedicated focus has enabled the MBP to become one of the largest academic based programs in the world. By relocating under the Office of Research, the MBP will be able to “Outgrow the Expected” and position UC Davis at the global epicenter of mouse based research.


The Mouse Biology Program (MBP) is an innovator of mouse models and molecular technologies that advance human health through reproducible research, higher education and next generation discovery.

Located on the campus of UC Davis, we are a unique academic research resource providing fully customized support for scientific research using genetically-altered mice. We offer investigators a "one-stop-shopping" approach by providing access to all essential services one would need to develop, plan, execute, and analyze a research project involving genetically-altered mice. Our products, services, and resources are designed for investigators at all levels of expertise, from novice to experienced. The MBP emphasizes high quality control and reproducibility for all services provided.

The MBP works closely with you to ensure your satisfaction. We provide a thorough description of your project, including alternative approaches, accurate timelines, and cost estimates. We emphasize regular and informative communication throughout your project, including email updates on the completion of each milestone. You can also follow the progress at each stage of your project by viewing detailed information anytime by accessing our online and secure project tracking system (PTS) available 24 hours a day. 

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