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Are You Interested in a Particular Gene

The IMPC is creating knockout mouse lines for every single protein coding gene in the mouse genome, and characterising them through standardised, quality-controlled phenotyping tests.

See the phenotypes for thousands of gene knockouts. Free database includes raw data, statistics, images, disease associations and interactive embryo viewer  at http://www.mousephenotype.org

Now Available CRISPR/Cas9 for RATS!

    The UC Davis Mouse Biology Program (MBP) is proud to make available genome editing in rats using CRISPR/Cas9 as a service to campus researchers. In addition to CRISPR mice, the MBP can now design, establish, and expand genome-edited rat models for your research.
    Rats studies can be advantageous for sequential blood and tissue sampling, especially in longitudinal drug studies. Rats are also valuable for research in neurological, behavior, and pharmacology studies, and more. The ability to efficiently modify the rat genome greatly expands these and other research opportunities using rats.
    MBP is pleased to offer the campus community CRISPR/Cas9 rat and mouse models for your research program. CRISPR/Cas9-based gene editing has emerged as a versatile approach for inducing precise genetic alterations. The MBP has the experience to deliver a variety of mutations, including indels, exdels, conditionals, and more, on diverse strain genetic backgrounds in mice and rats.
   Our team of experienced scientists and technical staff can help you select the best approach for your research project and guide you through your project's development.
The MBP is excited to expand our well established mouse services into a new species, rats, to better serve the needs of our campus researchers. Rat models are now available. Contact This email address is being protected from spambots. You need JavaScript enabled to view it.to start your order, Today!

 NIH Renews Knockout Mouse Program (KOMP)

The Mouse Biology Program (MBP), has been awarded over $29 million from the National Institutes of Health under the next five-year phase of the Knockout Mouse Project, or KOMP. The MBP at UC Davis is the lead organization in a consortium involving research partners at The Centre for Phenogenomics in Toronto, Canada; the Children’s Hospital Oakland Research Institute, or CHORI; and Charles River Laboratories in Wilmington, Massachusetts. 

The goal of this phase of the Knockout Mouse Project is to produce and phenotype knockout mouse models for up to 1,000 genes in an effort to better understand the genetic basis for diseases in humans and animals, said principal investigator Kent Lloyd, professor in the Department of Surgery in the UC Davis School of Medicine, and director of the UC Davis Mouse Biology Program

https://www.ucdavis.edu/news/human-animal-health