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IMPC: The Function of Human Genetic Variation

Download International Mouse Phenotyping Consortium strategy for 2021-2030 in PDF.

MMRRC Announces Availability of KOMP Repository Mice & ES Cells

The Mutant Mouse Resource and Research Center (MMRRC), the official National Institute of Health (NIH) repository of mouse models, is pleased to announce the availability of genetically-altered mice and embryonic stem (ES) cells made as part of the NIH Knockout Mouse Project (KOMP) and previously maintained in the KOMP Repository. The KOMP Repository collection will provide investigators with the convenience of a one-stop portal to one of the largest inventories of mutant mouse strains and ES cell lines available to the biomedical research community.

These newly acquired mouse and ES cell lines have been deposited into the MMRRC at UC Davis. The MMRRC at UC Davis is the largest of four regional archive and distribution centers in the NIH consortium. The MMRRC functions as a single repository resource and is comprised of an Informatics, Coordination and Service Center (ICSC) and three additional regional distribution facilities which include: The Jackson Laboratory, University of Missouri, and University of North Carolina, Chapel Hill. The newly available KOMP Repository mice (4,175 unique lines) & ES cell lines (14,013 unique mutant lines and 7 parental lines) can be accessed by visiting the MMRRC website (www.mmrrc.org) and typing in "KOMP Repository" in the search function, or by using the advanced search function and indicating “Major Collection = KOMP", and then searching by gene of interest, which will allow filtering for ES cells or mice.

The MMRRC was created in 1999, and is supported through the NIH, Office of Infrastructure and Research Programs (ORIP), as the nation’s premier mouse archive and distribution repository. Since that time, the MMRRC has earned an international reputation for the management, cryopreservation, and distribution of scientifically valuable, genetically engineered mouse strains and mouse ES cells. In partnership with researchers around the globe, the MMRRC continues to expand its holdings of mouse models. Today, with more than 59,000 available models, the MMRRC serves as a valuable resource to drive research discoveries for human disease.

Are You Interested in a Particular Gene

The IMPC is creating knockout mouse lines for every single protein coding gene in the mouse genome, and characterising them through standardised, quality-controlled phenotyping tests.

See the phenotypes for thousands of gene knockouts. Free database includes raw data, statistics, images, disease associations and interactive embryo viewer  at http://www.mousephenotype.org

MBP Rate Updates, Effective February 7, 2019

Mouse Biology Program (MBP) is happy to announce that our per diem rates are going down. These have been reviewed by campus, and approved.  Some of our other rates will be changing as well, taking into account the new per diem rates, and changes to supply costs. The new pricing will be posted and take effect as of February 7, 2019.   We will honor previously quoted rates for current projects with ongoing services, including new projects quoted and initiated prior to February 7, 2019.  Projects initiated after February 6, or any newly requested add-on services to existing projects, will be quoted and billed with the new approved rate(s).  

For more information about MBP’s new service rates, please click the “Contact Us” tab on the left-hand side of our website.

Now Available CRISPR/Cas9 for RATS!

    The UC Davis Mouse Biology Program (MBP) is proud to make available genome editing in rats using CRISPR/Cas9 as a service to campus researchers. In addition to CRISPR mice, the MBP can now design, establish, and expand genome-edited rat models for your research.
    Rats studies can be advantageous for sequential blood and tissue sampling, especially in longitudinal drug studies. Rats are also valuable for research in neurological, behavior, and pharmacology studies, and more. The ability to efficiently modify the rat genome greatly expands these and other research opportunities using rats.
    MBP is pleased to offer the campus community CRISPR/Cas9 rat and mouse models for your research program. CRISPR/Cas9-based gene editing has emerged as a versatile approach for inducing precise genetic alterations. The MBP has the experience to deliver a variety of mutations, including indels, exdels, conditionals, and more, on diverse strain genetic backgrounds in mice and rats.
   Our team of experienced scientists and technical staff can help you select the best approach for your research project and guide you through your project's development.
The MBP is excited to expand our well established mouse services into a new species, rats, to better serve the needs of our campus researchers. Rat models are now available. Contact This email address is being protected from spambots. You need JavaScript enabled to view it.to start your order, Today!

 NIH Renews Knockout Mouse Program (KOMP)

The Mouse Biology Program (MBP), has been awarded over $29 million from the National Institutes of Health under the next five-year phase of the Knockout Mouse Project, or KOMP. The MBP at UC Davis is the lead organization in a consortium involving research partners at The Centre for Phenogenomics in Toronto, Canada; the Children’s Hospital Oakland Research Institute, or CHORI; and Charles River Laboratories in Wilmington, Massachusetts. 

The goal of this phase of the Knockout Mouse Project is to produce and phenotype knockout mouse models for up to 1,000 genes in an effort to better understand the genetic basis for diseases in humans and animals, said principal investigator Kent Lloyd, professor in the Department of Surgery in the UC Davis School of Medicine, and director of the UC Davis Mouse Biology Program

https://www.ucdavis.edu/news/human-animal-health