UC Davis Mouse Biology Program Responds to Campus Fiscal Challenges
(June 24, 2020, DAVIS, CA) As the University of California Davis prepares for the fiscal impact of funding cuts in the state’s 2020-2021 budget due to the COVID-19 pandemic, the UC Davis Mouse Biology Program (MBP) is taking the unprecedented step by returning $275,000 from its reserve account to the University’s Office of the Provost. In the spirit of campus community, this generous donation comes at a time when the campus is facing unparalleled financial challenges as it deals with the effects of SARS-CoV-2. These funds will allow the Office of the Provost to support campus teaching and research programs with the greatest need.
UPDATE: June 8, 2020 MBP Operations Status
UC Davis and the UC Davis Mouse Biology Program continues to operate with limited on-site staff, as we move into the next phase of operations, Phase 2. We have been given campus authorization to resume some services, specifically those scheduled prior to the shutdown that were halted. Customer service will continue to operate remotely, and will work closely with you to ensure the safety and health of personnel, live animals, and research materials. We are not yet beginning new projects, with the exception of approved UCD research projects*, but can prepare necessary documentation in anticipation of Phase 3. We appreciate your understanding of delays experienced during this time.
MBP Now A Special Research Program Under Office Of Research
As the Mouse Biology Program (MBP) begins its third decade of service as a scientific resource for campus researchers, we are pleased to announce that effective March 1st we will join the UC Davis Office of Research. With operational and administrative oversight provided by the Office of Research, this move will place MBP in a better position to support the needs of campus investigators conducting research using mutant mice. This move will also better enable us to provide innovative products, unique services, and specialized infrastructure for research in areas of human and animal health and precision medicine. During this transition, we do not expect any slowdown in delivery or interruption of current or future orders and services to researchers.
Since 1997, the MBP has grown from one small laboratory to a large and vibrant organization playing an essential role in biomedical discovery by facilitating the availability and accessibility of next-generation mouse models and mouse mutagenesis and other strategies. This dedicated focus has enabled the MBP to become one of the largest academic based programs in the world. By relocating under the Office of Research, the MBP will be able to “Outgrow the Expected” and position UC Davis at the global epicenter of mouse based research.
Annual Stakeholder Report 2018-2019
Launching the Next Decade of Service
As we enter our 21st year of operation, it is time again for us in the UC Davis Mouse Biology Program (MBP) to highlight our many accomplish- ments, scientific activities, new technologies, and collaborations over the past year in support of the UC Davis campus community.
MMRRC Announces Availability of KOMP Repository Mice & ES Cells
The Mutant Mouse Resource and Research Center (MMRRC), the official National Institute of Health (NIH) repository of mouse models, is pleased to announce the availability of genetically-altered mice and embryonic stem (ES) cells made as part of the NIH Knockout Mouse Project (KOMP) and previously maintained in the KOMP Repository. The KOMP Repository collection will provide investigators with the convenience of a one-stop portal to one of the largest inventories of mutant mouse strains and ES cell lines available to the biomedical research community.
These newly acquired mouse and ES cell lines have been deposited into the MMRRC at UC Davis. The MMRRC at UC Davis is the largest of four regional archive and distribution centers in the NIH consortium. The MMRRC functions as a single repository resource and is comprised of an Informatics, Coordination and Service Center (ICSC) and three additional regional distribution facilities which include: The Jackson Laboratory, University of Missouri, and University of North Carolina, Chapel Hill. The newly available KOMP Repository mice (4,175 unique lines) & ES cell lines (14,013 unique mutant lines and 7 parental lines) can be accessed by visiting the MMRRC website (www.mmrrc.org) and typing in "KOMP Repository" in the search function, or by using the advanced search function and indicating “Major Collection = KOMP", and then searching by gene of interest, which will allow filtering for ES cells or mice.
The MMRRC was created in 1999, and is supported through the NIH, Office of Infrastructure and Research Programs (ORIP), as the nation’s premier mouse archive and distribution repository. Since that time, the MMRRC has earned an international reputation for the management, cryopreservation, and distribution of scientifically valuable, genetically engineered mouse strains and mouse ES cells. In partnership with researchers around the globe, the MMRRC continues to expand its holdings of mouse models. Today, with more than 59,000 available models, the MMRRC serves as a valuable resource to drive research discoveries for human disease.
Are You Interested in a Particular Gene
The IMPC is creating knockout mouse lines for every single protein coding gene in the mouse genome, and characterising them through standardised, quality-controlled phenotyping tests.
See the phenotypes for thousands of gene knockouts. Free database includes raw data, statistics, images, disease associations and interactive embryo viewer at http://www.mousephenotype.org
The Mouse Biology Program has an opening for a Project Scientist
Mouse Biology Program (MBP) is recruiting for a 80% Full Project Scientist.
Research activity (75%)
This position requires creative contributions to and collaborative development of an active research program investigating topics relevant to the research area of mouse biology, viability and phenotyping. The candidate will help to determine research goals in consultation with the Principal Investigator. He/she will participate in various mouse research projects, including the Knock Out Mouse Phenotyping Program Project (KOMP2). The overreaching goal of these projects is to develop, produce, and characterize mouse knockouts for each of the ~20,000 genes and variants of the mouse genome. Using her/his expertise in mouse developmental biology, embryology, histology and biostatistics, the candidate will contribute to
- the collection and phenotypic evaluation of embryo lethal and subviable mutants
- the phenotypic characterization of early and late adult mouse mutants
- planning, coordination, and analysis and interpretation of phenotyping data on variant models
- the review and analysis of data collected from models described above
- the participation on committees at the UCD-MBP, DTCC and IMPC levels
- the supervision and scheduling of students or technicians regarding the technical aspects of the research, including methods development, trouble-shooting problems, interpreting results and planning follow-up experiments
NIH Renews Knockout Mouse Program (KOMP)
The Mouse Biology Program (MBP), has been awarded over $29 million from the National Institutes of Health under the next five-year phase of the Knockout Mouse Project, or KOMP. The MBP at UC Davis is the lead organization in a consortium involving research partners at The Centre for Phenogenomics in Toronto, Canada; the Children’s Hospital Oakland Research Institute, or CHORI; and Charles River Laboratories in Wilmington, Massachusetts.
The goal of this phase of the Knockout Mouse Project is to produce and phenotype knockout mouse models for up to 1,000 genes in an effort to better understand the genetic basis for diseases in humans and animals, said principal investigator Kent Lloyd, professor in the Department of Surgery in the UC Davis School of Medicine, and director of the UC Davis Mouse Biology Program