UPDATE: May 27, 2020 MBP Operations Status
UC Davis continues to operate with limited staff, including at Mouse Biology Program, however we have been given campus authorization to resume some shipping, beginning with preserved cells and germplasm. We will work closely with receiving institutions and couriers, as there are still flight concerns, and so will begin with domestic shipments, and once we are satisfied can then resume international shipping. Live mouse shipments will begin in the second or third week of June, but again with consideration to an institution’s ability to receive, animals available to ship, and airline flights accepting live animals. We will continue to work closely with receiving institutions and couriers to ensure the safety and health of personnel and live animals.
MBP Now A Special Research Program Under Office Of Research
As the Mouse Biology Program (MBP) begins its third decade of service as a scientific resource for campus researchers, we are pleased to announce that effective March 1st we will join the UC Davis Office of Research. With operational and administrative oversight provided by the Office of Research, this move will place MBP in a better position to support the needs of campus investigators conducting research using mutant mice. This move will also better enable us to provide innovative products, unique services, and specialized infrastructure for research in areas of human and animal health and precision medicine. During this transition, we do not expect any slowdown in delivery or interruption of current or future orders and services to researchers.
Since 1997, the MBP has grown from one small laboratory to a large and vibrant organization playing an essential role in biomedical discovery by facilitating the availability and accessibility of next-generation mouse models and mouse mutagenesis and other strategies. This dedicated focus has enabled the MBP to become one of the largest academic based programs in the world. By relocating under the Office of Research, the MBP will be able to “Outgrow the Expected” and position UC Davis at the global epicenter of mouse based research.
Annual Stakeholder Report 2018-2019
Launching the Next Decade of Service
As we enter our 21st year of operation, it is time again for us in the UC Davis Mouse Biology Program (MBP) to highlight our many accomplish- ments, scientific activities, new technologies, and collaborations over the past year in support of the UC Davis campus community.
MMRRC Announces Availability of KOMP Repository Mice & ES Cells
The Mutant Mouse Resource and Research Center (MMRRC), the official National Institute of Health (NIH) repository of mouse models, is pleased to announce the availability of genetically-altered mice and embryonic stem (ES) cells made as part of the NIH Knockout Mouse Project (KOMP) and previously maintained in the KOMP Repository. The KOMP Repository collection will provide investigators with the convenience of a one-stop portal to one of the largest inventories of mutant mouse strains and ES cell lines available to the biomedical research community.
These newly acquired mouse and ES cell lines have been deposited into the MMRRC at UC Davis. The MMRRC at UC Davis is the largest of four regional archive and distribution centers in the NIH consortium. The MMRRC functions as a single repository resource and is comprised of an Informatics, Coordination and Service Center (ICSC) and three additional regional distribution facilities which include: The Jackson Laboratory, University of Missouri, and University of North Carolina, Chapel Hill. The newly available KOMP Repository mice (4,175 unique lines) & ES cell lines (14,013 unique mutant lines and 7 parental lines) can be accessed by visiting the MMRRC website (www.mmrrc.org) and typing in "KOMP Repository" in the search function, or by using the advanced search function and indicating “Major Collection = KOMP", and then searching by gene of interest, which will allow filtering for ES cells or mice.
The MMRRC was created in 1999, and is supported through the NIH, Office of Infrastructure and Research Programs (ORIP), as the nation’s premier mouse archive and distribution repository. Since that time, the MMRRC has earned an international reputation for the management, cryopreservation, and distribution of scientifically valuable, genetically engineered mouse strains and mouse ES cells. In partnership with researchers around the globe, the MMRRC continues to expand its holdings of mouse models. Today, with more than 59,000 available models, the MMRRC serves as a valuable resource to drive research discoveries for human disease.
Are You Interested in a Particular Gene
The IMPC is creating knockout mouse lines for every single protein coding gene in the mouse genome, and characterising them through standardised, quality-controlled phenotyping tests.
See the phenotypes for thousands of gene knockouts. Free database includes raw data, statistics, images, disease associations and interactive embryo viewer at http://www.mousephenotype.org
NIH Renews Knockout Mouse Program (KOMP)
The Mouse Biology Program (MBP), has been awarded over $29 million from the National Institutes of Health under the next five-year phase of the Knockout Mouse Project, or KOMP. The MBP at UC Davis is the lead organization in a consortium involving research partners at The Centre for Phenogenomics in Toronto, Canada; the Children’s Hospital Oakland Research Institute, or CHORI; and Charles River Laboratories in Wilmington, Massachusetts.
The goal of this phase of the Knockout Mouse Project is to produce and phenotype knockout mouse models for up to 1,000 genes in an effort to better understand the genetic basis for diseases in humans and animals, said principal investigator Kent Lloyd, professor in the Department of Surgery in the UC Davis School of Medicine, and director of the UC Davis Mouse Biology Program