The goal of Mouse Biology Shared Resource is to meet the needs of UC Davis Comprehensive Cancer Center investigators, utilizing genetically-altered mice for basic, clinical and translational research.
The Mouse Biology Shared Resource coordinates the activities of a number of campus resources to serve researchers using genetically altered mice as models for the study of cancer. These campus resources include the UC Davis Mouse Biology Program, the M3 Specific Pathogen Free (SPF) Barrier Facility, the Teaching and Research Animal Care Services, the Mutant Mouse Pathology Laboratory, the Comparative Pathology Laboratory, the Mutant Mouse Resource and Research Center, the Knockout Mouse Production and Phenotyping Project, and the Mouse Metabolic Phenotyping Center.
Under a limited time agreement, access to patient-derived xenograft (PDX) tumors maintained at JAX are being made available at no charge to members of the UC Davis Comprehensive Cancer Center. Most PDX’s are available from the cryopreserved archive, while a very few are also available as live mouse models.
Please go to the Mouse Tumor Biology (MTB) database at http://tumor.informatics.jax.org/mtbwi/index.do for the list of PDX tumors available to Cancer Center members.
Requests for tumors can be made by completing and submitting the request form in the Request JAX PDX Tumors including upload of a 1 page proposed study plan, to the Mouse Biology Shared Resource (MBSR). Your request will be reviewed by the PDX Program Oversight Committee for scientific merit, number and type of tumors, and availability of funding to enable utilization of the tumor. If approved, the PDX can either be delivered to your laboratory or to the MBSR which can establish, passage, characterize, and create cohorts of PDX mouse models for you at a substantially subsidized rate. Your only obligation is to redeposit the passaged tumor into the Cancer Center Biorepository Shared Resource (BSR) at the conclusion of your experiments…the MBSR can do that for you as well.
The National Cancer Institute (NCI) has established a national repository of PDX models (https://pdmr.cancer.gov/) comprised of patient cancers, in addition to in vitro patient-derived tumor cell cultures (PDCs), cancer associated fibroblasts (CAFs), and patient-derived organoids (PDOrg). These models serve as a resource for public and private research activities and for academic drug discovery efforts. These PDXs are clinically-annotated with molecular information available in an easily accessible database and available to the extramural community. To browse the catalog, please go to this link: https://pdmdb.cancer.gov/pls/apex/f?p=101:41
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