The Mouse Biology Program bioinformatics team has direct experience with mouse model research. The group designs and maintains systems for high throughput genotyping and phenotyping, including data collection, hosting, visualization, and analysis, dynamic web presentation, and publication quality reporting.
Here at the Mouse Biology Program (MBP), we have extensive experience with mouse breeding and colony management. Our trained professional staff can assist you with devising and implementing a breeding plan to generate the cohort or mouse model your research requires.
At the MBP, our cryopreservation and recovery services program provides you with the peace of mind and assurance that your research investment is protected. Our new advances in reproductive technologies allow us to cryopreserve and recover your mouse strains rapidly, reliably, and most important, cost-effectively.
The MBP offers a variety of services for mouse genotyping, customized to meet the needs of our clients.
At the MBP, we have extensive experience with live mouse imports to the UC Davis campus, both from domestic and international facilities and also have extensive experience with exporting live mice and mouse samples (tissues, germplasm, ES cells, etc) worldwide.
The MBP utilizes a variety of different techniques including BAC recombineering, Yeast Recombineering, Gibson Assembly Cloning, and traditional ligation to create the desired Constitutive Knockout (KO), Conditional Knockout (cKO), Knockin (KI) and Transgenic (Tg) vectors in the most efficient manner possible.
The goal of Mouse Biology Shared Resource is to meet the needs of UC Davis Comprehensive Cancer Center investigators, utilizing genetically-altered mice for basic, clinical and translational research.
The generation of genetically modified mice may be divided into two main categories: targeted integration (insertion or deletion) and random integration of DNA into the mouse genome.
The MBP provides investigators with a full range of morphological, metabolic, organismal, behavioral, and pathological assays that can be fully customized to characterize mutant mouse models as adults and embryos.
The Mouse Biology Program is proud to offer an extensive tissue quality control service designed to accommodate researchers working with tissue samples from various sources.
Strain rederivation is a management tool used to clean a mouse line from pathogen infection or to import mice into a barrier facility from an outside vivarium.
The MBP has over 20 years of experience collecting and cryopreserving mouse germplasm, which includes an established program for cryorecovering mouse strains.