Posted on January 29, 2025
The world-wide pandemic involving SARS-CoV2 in which high infectivity and pathogenesis necessitated the critical need for rapid and accurate preclinical modeling of this new virus. Unfortunately, the species-restricted tropism of the CoV2 spike protein towards human and not mouse ACE2, seriously hampered the ability to understand pathogenesis and potential efficacy…Read more
Posted on January 27, 2025
The 2023-2024 period marks 25 years of the UC Davis Mouse Biology Program (MBP) supporting the campus community’s mouse modeling needs. As it enters its 26th year, MBP continues to serve as the sole comprehensive in-house resource, offering specialized expertise, services, and training in the development, testing, and application of…Read more
Posted on January 27, 2025
The MiniMUGA genotyping array, a vital tool for genetic quality control in laboratory mice, has been updated to improve its performance. Used in over 40,000 genotyping tests, MiniMUGA helps research programs like the Collaborative Cross (CC) and the Mutant Mouse Resource and Research Centers (MMRRC). The latest updates fix previous…Read more
Posted on January 27, 2025
A groundbreaking study published in Nature Aging has revealed pivotal insights into the genetic mechanisms of aging, utilizing advanced mouse models to replicate human biological processes. This research holds promising implications for developing therapies aimed at extending health span and mitigating age-related decline. By employing genetically engineered mouse models, researchers explored how…Read more
Posted on January 27, 2025
A recent study published in The Journal of Neuroscience has provided new insights into the role of Dopamine Receptor 2 (D2R) in motor control. Researchers from the Korea Institute of Science and Technology and Seoul National University used optogenetics—a technique that uses light to control neuron activity—to selectively activate D2R in animal models. Their…Read more
Posted on January 4, 2024
The year (2022-2023) marks 24 years since the UC Davis Mouse Biology Program (MBP) began serving the mouse modeling needs of the campus community. Now entering its 25th year, the MBP remains the only one-stop in-house resource of unique expertise, services, and training in the creation, testing, and application of mouse models…Read more
Posted on August 23, 2023
Mouse Biology Program is in the process of an across the board rate review, affecting MBP, MMRRC at UC Davis, MMPC-Live at UC Davis, GMRC, and MBSR. Our rates will be updated as early as October 1, 2023. Orders submitted prior to that date will not be affected, however fees…Read more
Posted on May 2, 2023
Imagine the genome as a city with different neighborhoods, each having its function. Topologically associating domain (TAD) boundaries are like the fences that separate these neighborhoods, maintaining distinct regulatory territories. Disruption of these boundaries may interfere with regular gene expression and cause diseases, but the full impact remains unclear. Researchers…Read more
Posted on April 3, 2023
Mutant mouse genetic modifications have revolutionized biomedical research, enabling scientists to study specific gene mutations and their effects on biological processes. This study used data mining to investigate congenital abnormalities underlying the Microphthalmia, Anophthalmia, and Coloboma (MAC) spectrum disease, a group of eye malformations that cause childhood visual impairment. The…Read more
Posted on January 14, 2023
The UC Davis Health Department of Surgery has received $3.75 million to launch a high-profile center where researchers can study metabolic disorders using mouse models. The goal is to learn more about the same diseases in humans. The National Center for Metabolic Phenotyping of Mouse Models of Obesity and Diabetes…Read more