Knockout Models

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Leverage extensive experience creating advanced Knockout Mouse Models to explore gene function and disease mechanisms. Our knockout models allow researchers to fully or conditionally inactivate specific genes, providing crucial insights into their roles in biological processes and disease progression.

We use two primary approaches for generating knockout mice:

1. Gene Targeting in Embryonic Stem (ES) Cells: This precise method targets and deletes specific genes in mouse embryonic stem cells, which are then injected into blastocysts and implanted into surrogate mothers. This traditional approach is reliable and ideal for complex modifications, including conditional knockouts.
2. CRISPR/Cas9 Genome Editing in Zygotes: Using cutting-edge CRISPR/Cas9 technology, knockout models are created directly in mouse zygotes. This faster, more streamlined method allows for direct genome editing in early embryos, making it perfect for producing knockout models with high precision and shorter timelines.

Both methods are tailored to your research needs, enabling detailed exploration of gene function, disease mechanisms, and potential therapeutic targets. Choose our knockout models for accurate, reproducible results that drive impactful discoveries.

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• Design Your Mouse
• Conditional Models
• Design Consultation Services
• Genetically Humanized Mouse Models
• Knockin Models
• Knockout Models
• Molecular Construct
• PDX Models
• Rare Disease Models
• Surgical Mouse Models
• Transgenic Models