Knockin Models

Insert endogenous (e.g., stop codon) or foreign (e.g., green fluorescent protein) coding sequences at a specific locus in the mouse genome.

Enhance your research with custom Knockin (KI) Mouse Models precisely designed to meet your genetic needs. MBP offers two highly effective approaches to create accurate, reliable models for your studies:

• Embryonic Stem (ES) Cell Method: This approach involves inserting a genetically modified sequence into mouse embryonic stem cells, which are then injected into donor blastocysts and implanted into surrogate mothers. The resulting offspring express the inserted gene accurately, making this method ideal for projects requiring complex modifications or precise control over gene expression.
• CRISPR/Cas9 Gene Editing in Zygotes: The CRISPR/Cas9 system directly modifies the genome in mouse zygotes, enabling rapid, efficient insertion of genetic sequences at specific loci. This approach bypasses the need for ES cells, accelerating the creation of knockin models.

Both methods ensure the development of precise, reproducible models essential for studying gene function, disease mechanisms, and potential therapies. Researchers can achieve reliable results that drive impactful discoveries by leveraging MBP’s expertise—partner with MBP to create a custom KI model that perfectly aligns with your research goals.

• Design Your Mouse
• Conditional Models
• Design Consultation Services
• Genetically Humanized Mouse Models
• Knockin Models
• Knockout Models
• Molecular Construct
• PDX Models
• Rare Disease Models
• Surgical Mouse Models
• Transgenic Models