Genotyping Services
Use PCR-based genotyping services to determine and confirm the genetic identity of a mouse strain or embryonic stem cell line with accuracy and reliability. Mouse Biology Program provides specific detection genetic modifications, ensuring research integrity.
A wide range of gene-specific genotyping services is available, each tailored to accurately characterize genetic modifications in mouse models and ensure precise, reliable results. Services include:
- Allele-Specific PCR, Sanger Sequencing, and Loss-of-Allele Analysis: These techniques precisely define mutant alleles, genetic backgrounds, selectable markers (e.g., neomycin), and remnant sequences (e.g., loxP) from mouse DNA.
- Homologous Recombination Confirmation in ES Cells: We verify successful recombination events and proper integration of molecular constructs.
- Coding Sequence Validation: We ensure the fidelity of the coding sequence to avoid any unintended mutations or disruptions.
- Genomic Insertion Site Identification: We pinpoint the exact location of transgene insertions, preventing interference with essential genes.
- Off-Target Mutagenesis Detection: We check for unintended genetic changes outside the target region, ensuring your models’ genetic accuracy.
Our comprehensive approach ensures the precision and reliability of your mouse models, supporting your research with the highest standards of genetic validation.
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