Genetically Humanized Mouse Models

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We offer comprehensive gene editing services that enable the replacement of a specific mouse allele with its orthologous human allele. This advanced genetic modification allows researchers to create highly accurate mouse models that mimic human disease conditions. By introducing human alleles into the mouse genome, these models are invaluable for:

• Understanding Disease Pathophysiology: Our humanized mouse models provide critical insights into the underlying mechanisms of human diseases, helping you study how particular genetic variations influence disease progression and severity.
• Distinguishing Disease Association from Causation: Our models help differentiate between genetic variants associated with a disease and those that directly cause the condition. This distinction is essential for identifying potential therapeutic targets.
• Elucidating Patient-Specific Phenotypes: Tailored to mimic patient-specific genetic variations, these models allow you to investigate the genetic basis of unique phenotypes and study how these specific mutations manifest in human-like biology.
• Enabling Preclinical Testing and Drug Development: Humanized mouse models allow researchers to conduct preclinical tests in a more human-relevant system, thus enhancing the likelihood of translational success in drug development.

With our state-of-the-art CRISPR/Cas9 technology and experienced team, we provide seamless design, generation, and validation of these customized mouse models, empowering you to unravel the complexities of human genetics and disease.

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• Design Your Mouse
• Conditional Models
• Design Consultation Services
• Genetically Humanized Mouse Models
• Knockin Models
• Knockout Models
• Molecular Construct
• PDX Models
• Rare Disease Models
• Surgical Mouse Models
• Transgenic Models