Conditional Models

Control the time and/or cell type of an allele expressed in mice. A conditional mouse model enables precise control over gene function.  

We can design and create genetically engineered mice that express either a native or exogenous allele, which has been precisely modified for targeted gene manipulation. These modifications can include advanced strategies such as conditional knockouts, knock-out first approaches, or conditional by inversion (COIN) systems. These methods ensure that the engineered allele is responsive to enzymatic activity, such as Cre or Flp-o recombinase, which interact with strategically placed target sequences, like loxP or FRT sites.

This targeted approach allows researchers to precisely, spatially, and temporally control gene expression. For instance, gene expression can be turned on or off in a particular cell type (spatial control) or at specific developmental stages, such as post-natal periods (temporal control). This level of precision is invaluable for studying gene function, understanding disease mechanisms, and developing new therapeutic strategies by enabling researchers to manipulate genes in a controlled and reversible manner.

• Design Your Mouse
• Conditional Models
• Design Consultation Services
• Genetically Humanized Mouse Models
• Knockin Models
• Knockout Models
• Molecular Construct
• PDX Models
• Rare Disease Models
• Surgical Mouse Models
• Transgenic Models