The Common Fund’s Knockout Mouse Phenotyping Program (KOMP2) provides broad, standardized phenotyping of a genome-wide collection of mouse knockouts generated by the International Knockout Mouse Consortium (IKMC), funded by the NIH, European Union, Wellcome Trust, Canada, and the Texas Enterprise Fund.
The goal of the International Mouse Phenotyping Consortium (IMPC) is to discover functional insight for every gene by generating and systematically phenotyping 20,000 knockout mouse strains.
Funded by the NIH as part of the second phase of the Knockout Mouse Project (KOMP2), the DTCC Consortium is creating a repository of knockout mouse lines and phenotype data as part of an international effort to help researchers develop better models of human disease. University of California, Davis (UC Davis), Toronto Centre for Phenogenomics (TCP), Children’s Hospital Oakland Research Institute (CHORI) and Charles River have come together to form the DTCC Consortium for this 5-year research effort. In addition to the DTCC Consortium, the other KOMP2 participants include The Jackson Laboratory as well as the collaboration of Baylor College of Medicine, the Wellcome Trust Sanger Institute and the Medical Research Council (MRC) Harwell.
The MMPC is a National Institutes of Health-sponsored resource that provides experimental testing services to scientists studying diabetes, obesity, diabetic complications, and other metabolic diseases in mice. Our mission is to advance medical and biological research by providing the scientific community with standardized, high quality metabolic and physiologic phenotyping services for mouse models of diabetes, diabetic complications, obesity and related disorders. The six Centers are housed at outstanding academic institutions, staffed by experts in state-of-the-art technology. Researchers can ship mice to one of the Centers and obtain on a fee-for-service basis a range of complex exams used to characterize mouse metabolism, blood composition including hormones, energy balance and physical activity, eating and exercise, insulin resistance, organ function, metabolic fluxes and morphology, physiology, histology and measures of diabetic complications in heart, kidney, vasculature, eye, etc. Many tests are done in living animals and are designed to elucidate subtle to complex traits that would define models of metabolic disease.
The KOMP Repository is the final component of a more than $50 million trans-NIH initiative to increase the availability of genetically altered mice and related materials. The University of California, Davis (UC Davis) and Children's Hospital Oakland Research Institute (CHORI) in Oakland, Calif., are collaborating to preserve, protect, and make available about 8,500 types of knockout mice and related products available to the research community.
The MMRRC distributes and cryopreserves scientifically valuable, genetically engineered mouse strains and mouse ES cell lines with potential value for the genetics and biomedical research community. We are a national network of breeding and distribution facilities plus an information coordinating center serving together as NIH's premier repository of spontaneous and induced mutant mouse and cell lines. The MMRRC is supported by the National Institutes of Health.
The Comparative Pathology Laboratory (CPL) provides gross necropsy and histopathology services tailored for the diagnosis of spontaneous or infectious diseases in laboratory animals. We offer consultation on management and control strategies, and we field questions regarding the use of animal models in the study of human diseases. Consultation on experimental pathology procedures, such as post-mortem sample harvest or organ fixation can also be provided. CPL also serves the UC Davis campus as the research animal diagnostic laboratory.