Director: Kent Lloyd, D.V.M., Ph.D.
Video: Learn more about the expertise and resources offered to support Cancer Center researchers from Kent Lloyd, director of the Mouse Biology Shared Resource.
The goal of Mouse Biology Shared Resource is to meet the needs of UC Davis Comprehensive Cancer Center investigators, utilizing genetically-altered mice for basic, clinical and translational research.
The Mouse Biology Shared Resource offers many services, including:
- Mouse Model Creation Services (generation of knockout and transgenic mouse strains, gene targeting by homologous recombination in embryonic stem (ES) cells, procurement, importation and rederivation to generate pathogen-free mice, strain cryopreservation and resuscitation, assisted reproduction procedures)
- Mouse Husbandry and Maintenance Services (colony management, health surveillance and disease prevention, sharing and distribution of strains)
- Mouse Phenotyping Services (gross and microscopic pathology, small animal imaging procedures)
The Mouse Biology Shared Resource coordinates the activities of a number of campus resources to serve researchers using genetically altered mice as models for the study of cancer. These campus resources include the UC Davis Mouse Biology Program, the M3 Specific Pathogen Free (SPF) Barrier Facility, the Teaching and Research Animal Care Services, the Mutant Mouse Pathology Laboratory, the Comparative Pathology Laboratory, the Mutant Mouse Resource and Research Center, the Knock Out Mouse Project Repository, the Knockout Mouse Production and Phenotyping Project, and the Mouse Metabolic Phenotyping Center.
Accessing PDX tumors from the UCD PDX Bank at The Jackson Laboratory
Under a limited time agreement, access to PDX tumors maintained at JAX are being made available at no charge to members of the UC Davis Comprehensive Cancer Center. Most PDX’s are available from the cryopreserved archive, while a very few are also available as live mouse models.
Please go to the Mouse Tumor Biology (MTB) database at http://tumor.informatics.jax.org/mtbwi/index.do for the list of PDX tumors available to Cancer Center members.
Requests for tumors can be made by completing and submitting the request form in the 'Request Tumors' button below, including upload of a 1 page proposed study plan, to the Mouse Biology Shared Resource (MBSR). Your request will be reviewed by the PDX Program Oversight Committee for scientific merit, number and type of tumors, and availability of funding to enable utilization of the tumor. If approved, the PDX can either be delivered to your laboratory or to the MBSR which can establish, passage, characterize, and create cohorts of PDX mouse models for you at a substantially subsidized rate. Your only obligation is to redeposit the passaged tumor into the Cancer Center Biorepository Shared Resource (BSR) at the conclusion of your experiments…the MBSR can do that for you as well.
If you are ready to order, click the request button below, fill in the form, and submit. We will get back to you within 14 days.