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SERVICE DESCRIPTION Academic - UC* Academic - Non-UC** Industry Rate**
Informatics        
BioAnalytics BioAnalystics, such as genomic sequence data, hourly rate. $139.00 $201.27 $215.17
Professional Consultation Informatics Consultation, Managerial level, hourly rate $125.00 $181.00 $193.50
Programming Programmer, hourly rate $77.00 $111.50 $119.20
Molecular Biology        
Special Services (MGEL) Hourly rate for one-off services by the molecular biology technical staff $76.00 $110.05 $117.65
SNP Speed Congenics Per sample SNP analysis, for confirming % desired strain $151.00 $218.65 $233.75
Loss of Allele (LOA) ES cell Screening loss of native allele analysis for ES Cell plate screening, per 96-well plate $403.00 $583.54 $623.84
PCR SEQUENCING Sequencing of a PCR product, per sample, includes PCR $27.00 $39.10 $41.80
RACE Procedure Rapid amplification of cDNA ends, per clone, generally for confirming gene traps $285.00 $412.68 $441.18
QPCR Single Reaction/sample quantitative PCR analysis, does not detect zygosity $10.00 $14.48 $15.48
QPCR Double Rxn/sample quantitative PCR analysis, double reaction for determining zygosity or copy number $13.00 $18.82 $20.12
QPCR Development (per probe) Development of quantitative PCR, includes analysis, design, and ordering one probe, as well as validation and optimization $464.00 $671.87 $718.27
Protocol Incorporation Incorporation of an existing PCR protocol, per allele, including ordering primers and reagents $101.00 $146.25 $156.35
Standard PCR (per sample) Per sample cost for testing samples by PCR, does not include protocol development or incorporation if MBP has not yet run this protocol $13.00 $18.82 $20.12
Standard PCR Development Development of a standard PCR protocol, per allele, including analysis, design, and ordering Primers, as well as validation and optimization $483.00 $699.38 $747.68
Southern Blot per targeting arm--up to 18 samples with the same NEO probe               (expansion of ES cells not included) $1,602.00 $2,319.70 $2,479.90
CRISPR gRNA Design Design of CRISPR guides for InDel or ExDel services $258.00 $373.58 $399.38
CRISPR Insertion or Deletion guide construction Synthesis of CRISPR guides for InDel or ExDel services $1,355.00 $1,962.04 $2,097.54
CRISPR HDR guide & Oligo or SNP construction Design and synthesis of CRISPR guides and small oligos or SNPs $1,816.00 $2,629.57 $2,811.17
CRISPR guide and up to 3 kb DNA synthesis Design and synthesis of CRISPR guides and DNA of up to 3kb $2,677.00 $3,876.30 $4,144.00
CRISPR guide and 3 – 5 kb DNA synthesis Design and synthesis of CRISPR guides and DNA of 3kb up to 5kb $3,787.00 $5,483.58 $5,862.28
CRISPR guide and 5 – 7 kb DNA synthesis Design and synthesis of CRISPR guides and DNA of5kb up to 7kb $6,206.00 $8,986.29 $9,606.89
CRISPR guide and 7 – 9 kb DNA synthesis Design and synthesis of CRISPR guides and DNA of 7kb up to 9kb $8,625.00 $12,489.00 $13,351.50
CRISPR gRNA QC Quality control and assurance analysis of CRISPR guides $437.00 $632.78 $676.48
CRISPR Prep Prep of CRISPR reagents for microinjection $64.00 $92.67 $99.07
CRISPR Off‐Target Analysis Sequence analysis of potential off target effects from CRISPR targeting, per predicted locus, up to 4 samples. $211.00 $305.53 $326.63
Taqman Gene Expression (per tissue) Analysis of tissue for expected transgene expression $389.00 $563.27 $602.17
DNA Vector Design.QC Quality control analysis of DNA vectors, and design review $1,385.00 $2,005.48 $2,143.98
Full Vector Purification and Prep Prurificatoin and linearization of vectors used for targeting or transgenesis $848.00 $1,227.90 $1,312.70
Final Vector Prep Preparation of vector for electorporation or microinjection $220.00 $318.56 $340.56
Reproductive Technologies and Cryopreservation        
ICSI RESCUE Intracytoplasmic sperm injection (ICSI) for rescue of a mouse line, assisted in vitro fertilization (IVF), implant of embryos into pseudopregnant recipients into the mouse barrier facility, to live birth of pups, includes up to 2 procedures, house litter(s) up to 7 weeks of age, sample pups for genotyping purposes, health screening of recipient females, and provision of health report after weaning. $4,664.99 $6,754.90 $7,221.40
STRAIN REDERIVATION Rederivation of a mouse line from fresh spermincluding IVF procedures, implant of embryos into pseudopregnant recipients into the mouse barrier facility, to live birth of pups, includes up to 2 procedures, house litter(s) up to 7 weeks of age, sample pups for genotyping purposes, health screening of recipient females, and provision of health report after weaning. $3,878.20 $5,615.64 $6,003.46
STRAIN REDERIVATION BY LASER IVF rederivation of a mouse line from fresh sperm into a clean barrier facility using laser assisted IVF $4,270.20 $6,183.26 $6,610.28
EMBRYO CRYOPRESERVATION Cryopreservation of mouse embryos derived from IVF, including donor female purchase (standard strains such as B6/J, FVB, B6/N, CD1) for Heterozygous line, includes up to two IVF procedures, cryoarchiving up to 300 embryos. 1 year of storage fee included.   Homozygous line fees will vary, and may require additional breeding and cryo sessions. $2,347.11 $3,398.62 $3,633.33
EMBRYO TEST THAW‐CULTURE Thaw of one straw of embryos and culture to blastocyst stage, count % recovered and % developed. $224.00 $324.35 $346.75
EMBRYO TEST THAW TO PUPS Thaw of one straw of embryos and implant to pseudopregnant female, derive live births, count % recovered, % born. Not done in barrier, can be sampled for genotyping if requested, recipient can be submitted for health screening if requested at additional costs. Pups are euthanized prior to weaning. $612.73 $887.23 $948.51
EMBRYO RECOVERY Recovery of cryopreserved embryos, implant of embryos into pseudopregnant recipients into the mouse barrier facility, to live birth of pups, includes up to 2 procedures, house litter(s) up to 6 weeks of age, sample pups for genotyping purposes, health screening of recipient females, and provision of health report after weaning. $2,664.21 $3,857.78 $4,124.20
EMBRYO CRYO OF EXTRA EMBRYOS Cryopreservation of excess mouse embryos derived from rederivation or recovery procedures not needed for the embryo transfers. $307.00 $444.54 $475.24
SPERM CRYOPRESERVATION Cryopreservation of mouse sperm from up to 2 male mice. $468.05 $677.74 $724.55
SPERM RECOVERY Cryorecovery of mouse sperm, including IVF procedures, implant of embryos into pseudopregnant recipients into the mouse barrier facility, to live birth of pups, includes up to 2 procedures, house litter(s) up to 7 weeks of age, sample pups for genotyping purposes, health screening of recipient females, and provision of health report after weaning. $3,998.43 $5,789.73 $6,189.57
SPERM RECOVERY BY LASER IVF Same as sperm recovery, but includes use of ZyClone laser for assisted IVF procedures. $4,106.43 $5,946.11 $6,356.76
SPERM TEST THAW TO CULTURE Cryorecovery of mouse sperm, including IVF procedures and culture to blastocyst stage, count % 2 cell/total oocytes and % of 2 cell developed to blastocysts. $574.26 $831.53 $888.96
SPERM TEST THAW TO PUPS Cryorecovery of mouse sperm, including IVF procedures, implant to pseudopregnant female, derive live births, count % 2-cell/total oocytes, and % of implanted born, can be sampled for genotyping if requested, recipient can be submitted for health screening if requested at additional costs. Pups are euthanized prior to weaning. $1,018.24 $1,474.41 $1,576.23
IVF KIT Optimized media and reagents for performing in vitro fertilization (IVF), including protocols. $284.00 $411.23 $439.63
Sperm Cryo Kit Optimized media and reagents for performing sperm cryopreservation, including protocols. $216.00 $312.77 $334.37
SPERM MOTILITY‐MORPHOLOGY Collection and assessment of sperm morphology, including digital sperm photography, sperm motility, and a formal report on the assessments. 2 male mice per service. $334.34 $484.13 $517.56
SPERM COUNTS+PRODUCTION Testes and epididymus collection from 2 males, epididymal sperm count measurements, including tissue weights, homogenizations, counting sperm cells, and calculations. Sperm production measurements including weighing tissues, homogenizations, count spermatids and sperm cells, and calculations. Provcision of a formal report on the assessment. $437.63 $633.69 $677.45
SPERM VIABILITY + INTEGRITY Sperm collection from 2 males, and treatment, viability assessment, sperm membrane integrity assessment, sperm acrosome integrity assessment, digital sperm photography, provision of a formal feport on the assessment. $578.63 $837.86 $895.72
MALE FERTILITY ASSESSMENTS 2 males and 35 females per service, evaluate reproductive history, analyze project $2,256.11 $3,266.85 $3,492.46
SPECIAL SERVICE (MICL) Hourly rate for one-off services by the reproductive sciences technical staff $48.00 $69.50 $74.30
SPERM TEST THAW TO CULTURE‐Repository sperm Cryorecovery of mouse sperm held in the MMRRC or KOMP cryorepository, including IVF procedures and culture to blastocyst stage, count % 2 cell/total oocytes and % of 2 cell developed to blastocysts. $295.26 $427.54 $457.07
Cryo Storage        
Cryo Storage Fees ‐ 1 year One year prepaid of cryopreservation storage for one mouse strain (up to 20 embryo straws and/or 30 sperm vials). $147.00 $212.86 $227.56
Cryo Storage Fees ‐ 3 years Three years prepaid of cryopreservation storage for one mouse strain (up to 20 embryo straws and/or 30 sperm vials). $311.00 $450.33 $481.43
Cryo Storage Fees ‐ 5 years Five years prepaid of cryopreservation storage for one mouse strain (up to 20 embryo straws and/or 30 sperm vials). $499.00 $722.55 $772.45
Project Management and Import/Export Services        
Special Services (MRPM) Hourly rate for one-off services by a Project manager or repository technician $64.00 $92.67 $99.07
Domestic Packaging and Handling 28 x 23 x 18cm Carton and insulated container, up to 3kg of dry ice, or ice packs, retrieving, packing and preparing for shipment $68.00 $98.46 $105.26
International Packaging and Handling 35.6 x 35.6 x 25.4cm Carton and insulated container, up to 10kg dry ice or ice packs, retreiving, packing and preparing for shipment $189.00 $273.67  
Order Processing Order initiation, including preparation of estimate, processing payment details, use agreements, billing service, hourly rate $64.00 $92.67 $99.07
Strain/Project Management Project management services, including strain breeding management, ensuring project flow, timely completion, deliverables met $67.00 $97.02 $103.72
Importation Coordinating importation of mice, germplasm, tissue, or cells from outside institutions or companies to UC Davis campus $148.00 $214.30 $229.10
Exportation Coordination of exportation of mice, germplasm, tissue, or cells to outside institutions from UC Davis campus $114.00 $165.07 $176.47
Curation Strain curation for cataloging and publication purposes $65.00 $94.12 $100.62
Shipping, Courier Fees Pass through of courier fees if we use our courier account $1.00 $1.45 $1.55
Additional Handling Extra documentation preparation or other special handling of shipments $32.00 $46.34 $49.54
Vapor Shipper Preparation and Handling Fill and charge the nitrogen dry shippers, preparing it for a maximum hold time, including assurance of routine QC of our MBP shippers $100.00 $144.80 $154.80
Contract or License Processing fee Processing business contracts, KOMP license payments, other agreements handling documents, communications and followup with campus, accounts payables, and IP agents. $352.00 $509.70 $544.90
MBP or KOMP Products        
First Mutant ES Cell Clone Clone purchase, expansion, assessment, genotyping protocol development (PCR, qPCR, and/or LRPCR) and analysis, pathogen testing, 1 vial $1,378.00 $1,995.34 $2,133.14
Additional ES Cell Clone, same Mutation Clone purchase, expansion, assessment, genotype analysis, pathogen testing (protocols already developed with first clone), 1 vial $663.00 $960.02 $1,026.32
Ultra Low Passage Parental ES Cells High quality cells at ultra low passage for creating multiple targeted genes, 1 vial $1,410.00 $2,041.68 $2,182.68
Low Passage Parental ES Cells High quality cells at low passage for targeting one gene, 1 vial $608.00 $880.38 $941.18
High Passage Control ES Cells Quality cells at high passage suitable for DNA analysis, wild type controls, non-targeting use, 1 vial $134.00 $194.03 $207.43
Irradiated Feeder Cells for ES Cell Culture One vial of feeder cells used for plating and growing ES cells on, the cells are irradiated prior to expansion and use, and are usually purchased in conjunction with other products. $146.40 $211.99 $226.63
Live Mutant Mouse Per live mutant mouse, generally breeder age, and genotyped. $458.45 $663.84 $709.68
Cryopreserved Sperm One aliquot of sperm sufficient for fertilizing multiple clutches of oocytes. $563.48 $815.92 $872.27
Cryopreserved Embryos One aliquot of embryos, generally 20 - 25 embryos, sufficient for transfer to 1 or 2 embryo recipients $1,001.56 $1,450.26 $1,550.42
Guaranteed Embryos One aliquot of embryos, generally 20 - 25 embryos, sufficient for transfer to 1 or 2 embryo recipients, if your recovery is not successful MBP will recover the line for you. $1,739.20 $2,518.36 $2,692.28
ES Cell work        
Special Service (MSCL) ES Cell special handling or technician services, hourly rate $62.00 $89.78 $95.98
Electroporation Per target, electroporation, picking up to 3 x 96 well plates, selection, passing, freezing, expansion of 12 clones, mycoplasma testing up to 4 clones, preparing up to 3 for injections. $4,240.00 $6,139.52 $6,563.52
CRISPR ES cell targeting Per target, crispr es cell targeting, picking 1 x 96 well plate, selection, passing, freezing, expansion of 12 clones, mycoplasma testing up to 4 clones, preparing up to 3 for injections. $3,585.00 $5,191.08 $5,549.58
Recombinase Electroporation (Flp and CRE) Electroporation of a positive clone with recombinase (CRE or FLP), includes feeder preparation, passing picking, feeding, expansion of up to 12 clones, mycoplasma testing of up to 4 clones, preparing 3 clones for injections. $3,280.00 $4,749.44 $5,077.44
Clone Expansion Expansion of an ES Cell clone from one to many vials, including feeders if needed, freezing down, and mycoplasma testing $256.00 $370.69 $396.29
Chromosome Counting Preparing cells and counting 20 spreads to derive % euploidy $266.00 $385.17 $411.77
Subcloning Picking 1 X 96 plates, expansion of up to 12 clones and freezing down, prepping for BL injection, chromosome counting of 6 clones. $4,305.00 $6,233.64 $6,664.14
Embryo Targeting and Transgenics        
Basic ESC Injection (Inbred) Inject up to 3x ES Cell cones per gene, inject 30-40 inbred donor embryos per clone, embryo transfer into up to 6 recipients, derive at least 10 pups, and house pups until 7 weeks of age. There are no guarantees for derivation of high percent chimeric mice with basic microinjection services. $7,668.32 $11,103.72 $11,870.55
Basic ESC Injection (Outbred) Inject up to 3x ES Cell cones per gene, inject 30-40 outbred donor embryos per clone, embryo transfer into up to 6 recipients, derive at least 10 pups, and house pups until 7 weeks of age. There are no guarantees for derivation of high percent chimeric mice with basic microinjection services. $4,654.88 $6,740.27 $7,205.76
Basic DNA Pronuclear Injection (Inbred) Includes injection of up to 180 and transfer of up to 120 injected zygotes, or obtaining 35 live pups, or generating 2 founders, whichever comes first. Inbred donors (B6, FVB) $6,438.86 $9,323.47 $9,967.36
Basic DNA Pronuclear Injection (Hybrid) Includes injection of up to 180 and transfer of up to 120 injected zygotes, or obtaining 35 live pups, or generating 2 founders, whichever comes first. Inbred donors (B6D2F1) $5,786.86 $8,379.37 $8,958.06
CRISPR Basic Targeting This CRISPR service includes microinjection or electroporation of up to 100 fertilized zygotes (B6, FVB), and embryo transfers in up to 4 pseudopregnant recipients, and housing of born mice for up to 10 weeks. Service is for InDels or ExDels, and is intended to generate at least 1 genotypically confirmed founder.  $4,846.34 $7,017.50 $7,502.13
CRISPR Advanced Targeting This CRISPR service includes microinjection or electroporation of up to 160 fertilized zygotes (B6, FVB), and embryo transfers into 6 - 8 pseudopregnant recipients, and housing of born mice for up to 10 weeks.   Service is for SNP, Homology Directed Repair, or Homologous Recombination, and is intended to generate at least 1 genotypically confirmed founder.  $9,641.67 $13,961.14 $14,925.31
SPECIAL SERVICE (MTGL) Hourly rate for one-off services by the microinjection technical staff $67.00 $97.02 $103.72
Phenotyping Services        
SPECIAL SERVICES IN‐LIFE (PHENO) Hourly rate for one-off services by an in vivo phenotyping technician $74.00 $107.15 $114.55
SHIRPA Standardized procedures for testing cerebellar, muscle, sensory and neuropsychiatric functions, per mouse. $20.00 $28.96 $30.96
PHYSICAL EXAM Gross exam per mouse. $4.00 $5.79 $6.19
ATAXIA (TREADSCAN) Per mouse treadscan and basic raw data analysis. $25.00 $36.20 $38.70
OPEN FIELD 1 - 8 mice per run, cost is per run. $50.00 $72.40 $77.40
ACOUSTIC STARTLE per run, up to 6 mice per run $22.00 $31.86 $34.06
MORRIS WATER MAZE (FEMALE) up to 16 mice over 5 days, females have additional analysis on day 5 $2,104.00 $3,046.59 $3,256.99
MORRIS WATER MAZE (MALE) up to 16 mice over 5 days $1,804.00 $2,612.19 $2,792.59
RADIAL ARM MAZE up to 16 mice over 10 days $3,484.00 $5,044.83 $5,393.23
INJECTIONS (IP,SUBQ,PO,IM) Dosing with injectible or oral medication or treatment $4.00 $5.79 $6.19
FOOD OR WATER INTAKE per cage, often one mouse per cage $7.00 $10.14 $10.84
BODY WEIGHT per mouse $4.00 $5.79 $6.19
Y‐MAZE per mouse $17.00 $24.62 $26.32
BLOOD COLLECTIONS (SUBMAN.,SAPH.) includes processing for serum or plasma, cost is per mouse $21.00 $30.41 $32.51
SOCIAL NOVELTY testing is over 2 days, cost is per mouse $64.00 $92.67 $99.07
PASSIVE AVOIDANCE testing is over 3 days, cost is per mouse $53.00 $76.74 $82.04
PROJECT MANAGEMENT Phenotyping specialist, project management and consulting, hourly rate $95.00 $137.56 $147.06
ACCELERATING ROTAROD per mouse $59.00 $85.43 $91.33
X‐RAY Xray or DEXA imaging per mouse, includes anesthesia $31.00 $44.89 $47.99
Special Service After‐life (PHENO) Ex vivo services, hourly rate for one-off technician services $80.00 $115.84 $123.84
Blood Collection (Cardiac) Cardiac blood collection, terminal, per mouse $24.00 $34.75 $37.15
Basic Necropsy Basic necropsy includes collection of major organs and snap freezing or PFA or Formalin fixing, fee is per mouse $36.00 $52.13 $55.73
Advanced Necropsy Advanced necropsy includes anything outside of the basic necropsy and/or special fixative procedures, major organs can also be a part of this necropsy, per mouse fee $68.00 $98.46 $105.26
LacZ Whole Mount Perfusion, specialized necropsy, and organ whole-mount staining for LacZ (per mouse), basic annotation $245.00 $354.76 $379.26
Patient and Pet Derived Xenograft services (PDX/PetDX)        
Primary Tumor Implant - PDX 1-5 Mice Includes supplies (anesthesia, media, and consumables) and labor for surgical implant into 1 - 5 mice, first month monitoring, body weights and measuring of the mice and tumors for the first month (2 - 3 times weekly dependent on growth rate, medical waste collections, collection of tumor for passage or freezing, and transfer of tumor to Med center or other. $1,051.00 $1,521.85 $1,626.95
Primary Tumor Monthly Monitoring 1-5 Mice Includes monthly monitoring of body weights and measuring of the mice and tumors, medical waste, per each following month. $531.00 $768.89 $821.99
Primary Tumor Implant - PDX 1-5 Mice CC Member Includes supplies (anesthesia, media, and consumables) and labor for surgical implant into 1 - 5 mice, first month monitoring, body weights and measuring of the mice and tumors for the first month (2 - 3 times weekly dependent on growth rate, medical waste collections, collection of tumor for passage or freezing, and transfer of tumor to Med center or other; specific to UCD Comprehensive Cancer Center Members. $949.00 $1,374.15 $1,469.05
Primary Tumor Monthly Monitoring 1-5 Mice CC Member Includes monthly monitoring of body weights and measuring of the mice and tumors, medical waste, per each following month; specific to UCD Comprehensive Cancer Center Members. $463.00 $670.42 $716.72
Animal Care and Housing        
Special Service Rate (VIV) Special services by Animal Technical staff, hourly rate $60.00 $86.88 $92.88
Cesarean Rederivation   $1,198.54 $1,735.49 $1,855.34
Small Crate Packing Sterilized small mouse crate, 1 - 2 sections, including food, gel, preparation and packing $86.00 $124.53 $133.13
Large Crate Packing Sterilized large mouse crate, 1 - 4 sections, including food, gel, preparation and packing $129.00 $186.79 $199.69
Animal order fee Vendor order placement $14.00 $20.27 $21.67
Professional Service Fee per Hour DVM hourly rate $143.00 $207.06 $221.36
Delivery/Vehicle Charge Delivery of items to/from campus, including use of Vivarium vehicle $76.00 $110.05 $117.65
Conventional Housing Per Diem Housing of mice in a conventional facility, 1 - 5 mice per cage, per cage per day $1.23 $1.78 $1.90
Barrier Housing Per Diem Housing of mice in a barrier facility, 1 - 4 mice per cage, per cage per day $1.85 $2.67 $2.86
Colony Management Colony management including breeding, weaning, sampling, monitoring, per cage per day $0.53 $0.77 $0.83
Immunodeficient Per Diem Housing of immunodeficient mice, 1 - 5 mice per cage $1.61 $2.34 $2.50
2nd St NSG NSG mouse from conventional facility $105.96 $153.42 $164.02
M3 CD‐1 ICR/CD1 mouse from barrier facility $21.14 $30.61 $32.73
M3 B6 C57BL/6 mouse from barrier facility $61.60 $89.20 $95.36
M3 Pseudopregnant Animal Pseudopregnant ICR/CD1 mouse $101.41 $146.83 $156.98
2nd B6 3‐5 wks old C57BL/6 mouse from conventional facility, 3 - 5 weeks of age $20.07 $29.07 $31.07
2nd B6 6 ‐9 wks C57BL/6 mouse from conventional facility, 6 - 9 weeks of age $30.41 $44.04 $47.08
         

The University of California, Davis, Mouse Biology Program (MBP) is a coordinated, campus-supported teaching, research, and service resource of infrastructure and fundamental expertise directed at developing, promoting, and enhancing the use of mouse model systems for understanding and resolving biological problems. Service rates listed here are university approved and subject to change.

If eligible, UC Davis Cancer Center members may receive a discount on Cancer related research. 

Prices listed subject to change (last update 03/08/2018). Request a quote from MBP Customer Service (This email address is being protected from spambots. You need JavaScript enabled to view it.) for your project.

* Payment must be made from a UC account. Shipping, order processing, and crate or box fees are extra.

** Invoices will be emailed to the client. Shipping, order processing and crate or box fees are extra.

 

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