Why Mice?

The Mouse Biology Program (MBP) at University of California, Davis (UC Davis) has the answer…

Since the early 1900’s mice have consistently been the animal model of choice to study human disease.   Despite recent introductions of other vertebrate animal models, mice still represent the number one research choice as disease models. 

Since more than 95% of the mouse genome is similar to that of humans, it is easy to understand why the majority of animal research is conducted using mice.  

 

Why work with the Mouse Biology Program at UC Davis? 

  1. The MBP, through its Knockout Mouse (KOMP) Program and participation in the Mutant Mouse Regional Resource Centers (MMRRC), has more than 50,000 unique mouse alleles available to the research community.  
  2. Working with mice allows for the manipulation of the mouse genome to model specific diseases for research where the causative gene is known.  The MBP offers products and services to efficiently target and edit the mouse genome for creating unique mouse models for the study of human disease.
  3.  At MBP, products and services for creating and studying mouse models are reasonably priced, saving investigators valuable time and resources.
  4. Mice are instrumental in research identifying genetic risk factors in the human population. The MBP provides researchers with direct online access to thousands of knockout and other custom-built mouse models to facilitate the study of human disease.
  5. Genetic background can strongly influence clinical signs or “phenotype” caused by knocking out disease genes in mice. The diversity of genetic backgrounds available for research allows one to fine-tune mouse models to best resemble human disease.  The MBP, through its Mouse Metabolic Phenotyping Center and KOMP Phenotyping Project, provides investigators standardized, high quality metabolic and physiologic phenotyping tests not available in other models.
  6. There are more numerous established embryonic stem (ES) cell lines in mice than in any other species used to study human disease.  The KOMP/MMRRC repository offers a wide array of ES cell lines available by searching the online database.
  7. Advances in genome editing technologies like CRISPR/Cas9 are being implemented that further enhance generations of novel mouse models of human disease.  The MBP can custom design and create genome editing projects in mice for your research needs.  
  8. Reliable cryopreservation protocols for mouse germplasm (sperm and embryos), facilitates ease of long term storage, protection and sustainability of models.  The MBP provides cryopreservation, storage, and cryorecovery services to assure long term protection and future accessibility of your research investment. 
  9.  The largest availability of reagents are optimized for the study of mouse tissues, cells and fluids.  The MBP has a strong reputation and proven track record of being a sustainable provider of mutant mouse models to the greater academic and research community, worldwide.
  10.  Continued R & D investment in the creation and studying of mouse models of human disease, developmental defects and behavioral disorders has remained strong for over 100 years.  For more than 15 years, the MBP and its associated creation, repository and phenotyping programs have provided the scientific community with next-generation mouse production, services and procedures relevant to the study of human disease. 

To learn more about how you can take advantage of the products and services available through the Mouse Biology Program at UC Davis, visit www.mousebiology.org today.

Your next Mouse Model is only a Mouse click away!