The Mouse Biology Program (MBP)

 

The UC Davis Mouse Biology Program (MBP) is an academic resource providing scientific expertise and consultation, technological assistance, dedicated infrastructure, and educational support to the academic community in the development, application, and use of genetically-altered mice for biomedical research on diseases, behavioral abnormalities, and developmental disorders.

 

Our Mission

Our mission is to serve as an innovator in mouse models and genomic services that advance human and animal health through education, research and discovery.

 

Our Vision

Our vision is to be a global leader in precision animal modeling that inspires the evolution of personalized medicine. We seek to pursue new and innovative technologies, develop novel resources, and embrace opportunities to collaborate with like-minded partners committed to transforming biomedical research.

We fulfill our mission and accomplish our vision by acting as a team. We value cooperation, respect, honesty, service, support, accountability and teamwork. We provide the foundation for exceptional service and innovative research utilizing high quality genetically engineered mouse models. We work together each day to foster a supportive learning environment, encouraging people to strive for their personal best while meeting organizational and research goals for growth and innovation. We take personal pride in the quality and reliability of our products and services, and remain passionate in the pursuit of our objectives and commitment to our values.

 

Our Background

The MBP is a scientific “utility” at UC Davis, providing services essential for biomedical research operations at a top tier university and health system working to maintain its scientific competitiveness and leadership. We are also recognized internationally as a world-class center of excellence in mouse embryo manipulation, genome-wide mutagenesis, and whole animal phenotyping and analysis.  Since its inception in 1997, the MBP has consistently pursued and successfully achieved significant extramural research funding from the NIH, and has been instrumental in facilitating campus investigators secure funding for their research programs. 

MBP operations are carried out by more than 100 scientists and technical staff in multiple interacting specialized laboratories housed in approximately 40,000 ASF of dedicated space in three facilities (the main headquarters, a dedicated high-containment barrier vivarium, and a bioinformatics center). With an interdisciplinary group of collaborating scientists, technical and trained customer service staff, the MBP has earned the reputation as a leading research, resource and repository epicenter for the highest quality genetically-altered mouse models and services for the biomedical research community.

The MBP is unique from all other mouse genetics and resource programs in that it provides professional, customized services related to mutant mouse biology that cannot be met by commercial providers or by other academic centers that provide institution-specific services to their local investigator community. The MBP conducts primary, resource-related research and collaborative, hypothesis-based research, participates in undergraduate, graduate, and professional level teaching and training, and provides products, services, and procedures in the fields of genetics and genomics, reproductive biology, pathology, physiology, cryobiology, developmental biology, bioinformatics, systems biology, and comparative and translational medicine.

The MBP has contributed several innovations in mouse mutagenesis, biorepository operations, education and training, and best practices for core shared resources. By identifying new and improving extant technologies and procedures in the use of genetically-altered mouse models, the MBP has positioned itself well to assist researchers by targeting new approaches to biomedical and translational research. In particular, the MBP focus its efforts in a number of key areas of opportunity, including genome editing, specialized colony management, enhanced cryoarchiving and biobanking, specialized phenotyping and imaging, and modeling disease genomes and cellular networks, and in the development of new, next-generation mutant mouse models for advancing the rapidly evolving areas of genomically-based molecular medicine and precision-guided diagnostics, therapeutics, and prevention.

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